Article
Protein kinase C alpha activates RAF-1 by direct phosphorylation.
Nature - 15 Jul 1993
Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marmé D, Rapp U R
Abstract excerpt
The kinase Raf-1 can be activated by treatment of cells with mitogens and by the protein kinase C (PKC) activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) (reviewed in refs 1,2). Activated Raf-1 triggers a protein kinase cascade by direct phosphorylation of MAP kinase kinase, resulting in phos...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Cloning, Molecular
- Enzyme Activation
- Escherichia coli
- Mice
- Molecular Sequence Data
- Moths
- Mutation
- Peptides
- Protein Kinase C
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Rats
- Recombinant Proteins