Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension.

doi:10.1165/rcmb.2005-0103OC

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension.

American journal of respiratory cell and molecular biology - 1 Nov 2005

Wong Wai K P, Knowles James A, Morse Jane H

Abstract excerpt

Mutations of bone morphogenetic protein receptor type II (BMPR-II) have been associated with familial and idiopathic pulmonary arterial hypertension (PAH). BMPR-II is a member of the transforming growth factor-beta receptor superfamily. It consists of extracellular, transmembrane, and kinase domains, and a unique C-terminus with mostly unknown function. However, a number of PAH-causing mutations are predicted to...

Topics

Bone Morphogenetic Protein Receptors, Type II
Bone Morphogenetic Proteins
CSK Tyrosine-Protein Kinase
Cells, Cultured
Cytoplasm
Humans
Hypertension, Pulmonary
Immunoprecipitation
Lung
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocytes, Smooth Muscle

Phosphorylation

Protein Structure, Tertiary

Protein-Tyrosine Kinases

Two-Hybrid System Techniques

Tyrosine

src-Family Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 16002577
DOI: 10.1165/rcmb.2005-0103OC
PMCID: PMC2715351

Genes

PAH
BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension.PMID 16002577Read ↗

Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension.Semantic proximity Read ↗

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension.Semantic proximity Read ↗

Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.Semantic proximity Read ↗

Heterozygous Null Bone Morphogenetic Protein Receptor Type 2 Mutations Promote SRC Kinase-dependent Caveolar Trafficking Defects and Endothelial Dysfunction in Pulmonary Arterial HypertensionSemantic proximity Read ↗

The carboxy‐terminus of the human ARPKD protein fibrocystin can control STAT3 signalling by regulating SRC‐activationSemantic proximity Read ↗

Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.Semantic proximity Read ↗

Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension.Semantic proximity Read ↗

Saracatinib and Dasatinib Fail To Prevent Heritable Pulmonary Arterial HypertensionSemantic proximity Read ↗

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1.Semantic proximity Read ↗

Trapping of BMP receptors in distinct membrane domains inhibits their function in pulmonary arterial hypertension.Semantic proximity Read ↗

Regulation and targets of receptor tyrosine kinases.Semantic proximity Read ↗

Functional significance of SRJ domain mutations in CITED2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.