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Article

Mutational and structural analysis of the binding interface between type I interferons and their receptor Ifnar2.

Journal of molecular biology - 19 Nov 1999

Piehler J, Schreiber G

Abstract excerpt

Type I interferons (IFN) exert pleiotropic activities through binding to two cell surface receptors, ifnar1 and ifnar2. We are investigating the biophysical basis of IFN signaling by characterizing the complex of the extra-cellular domain of ifnar2 (ifnar2-EC) with IFNs on the level of purified recombinant proteins in vitro. Here, we present a detailed mutational study on the functional epitopes on both IFN and...

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Identifiers

PMID: 10556041
DOI: 10.1006/jmbi.1999.3230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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