Familial and population-based studies of apolipoprotein E and Alzheimer's disease.

doi:10.1111/j.1749-6632.1996.tb32594.x

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Article

Familial and population-based studies of apolipoprotein E and Alzheimer's disease.

Annals of the New York Academy of Sciences - 16 Dec 1996

Mullan M, Scibelli P, Duara R, Fallin D, Gold M, Schinka J, Hoyne J, Osborne A, Sevush S, Crawford F

Abstract excerpt

The finding of an association between the epsilon 4 allele of the APOE locus and the early expression of late-onset Alzheimer's disease (AD) is robust. However, the estimates of the proportion of AD cases carrying one or more copies of the epsilon 4 allele vary dramatically between studies (highe...

Topics

Age of Onset
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Family
Florida
Gene Frequency
Genotype
Humans
Nuclear Family
Odds Ratio
Risk Factors

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