Article
Familial and population-based studies of apolipoprotein E and Alzheimer's disease.
Annals of the New York Academy of Sciences - 16 Dec 1996
Mullan M, Scibelli P, Duara R, Fallin D, Gold M, Schinka J, Hoyne J, Osborne A, Sevush S, Crawford F
Abstract excerpt
The finding of an association between the epsilon 4 allele of the APOE locus and the early expression of late-onset Alzheimer's disease (AD) is robust. However, the estimates of the proportion of AD cases carrying one or more copies of the epsilon 4 allele vary dramatically between studies (highest estimates being 180% of lowest ones). Here we compare the results of association studies in samples drawn from an...
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