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Article

The meiosis-specific protein kinase Ime2 directs phosphorylation of replication protein A.

The Journal of biological chemistry - 13 Feb 2004

Clifford Dawn M, Marinco Suzanne M, Brush George S

Abstract excerpt

In Saccharomyces cerevisiae, the cellular single-stranded DNA-binding protein replication protein A (RPA) becomes phosphorylated during meiosis in two discrete reactions. The primary reaction is first observed shortly after cells enter the meiotic program and leads to phosphorylation of nearly all the detectable RPA. The secondary reaction, which requires the ATM/ATR homologue Mec1, is induced upon initiation of...

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Source

Identifiers

PMID: 14634024
DOI: 10.1074/jbc.M306943200

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The meiosis-specific protein kinase Ime2 directs phosphorylation of replication protein A.PMID 14634024Read ↗

Evidence of meiotic crossover control in Saccharomyces cerevisiae through Mec1-mediated phosphorylation of replication protein A.Semantic proximity Read ↗

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.Semantic proximity Read ↗

Phosphorylation of Ime2 regulates meiotic progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

PP2A (Cdc)⁵⁵ is required for multiple events during meiosis I.Semantic proximity Read ↗

Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.Semantic proximity Read ↗

The Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p.Semantic proximity Read ↗

Shared roles of yeast glycogen synthase kinase 3 family members in nitrogen-responsive phosphorylation of meiotic regulator Ume6p.Semantic proximity Read ↗

Replication protein A (AtRPA1a) is required for class I crossover formation but is dispensable for meiotic DNA break repair.Semantic proximity Read ↗

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