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The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus

15 Mar 2005

Abstract excerpt

Poliovirus selectively replicates in neurons in the spinal cord and brainstem, although poliovirus receptor (PVR) expression is observed in both the target and nontarget tissues in humans and transgenic mice expressing human PVR (PVR-transgenic mice). We assessed the role of alpha/beta interferon (IFN) in determining tissue tropism by comparing the pathogenesis of the virulent Mahoney strain in PVR-transgenic...

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Identifiers

PMID: 15767446
DOI: 10.1128/jvi.79.7.4460-4469.2005

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