Article
Molecular analysis of the Mov 34 mutation: transcript disrupted by proviral integration in mice is conserved in Drosophila.
Development (Cambridge, England) - 1 May 1990
Gridley T, Gray D A, Orr-Weaver T, Soriano P, Barton D E, Francke U, Jaenisch R
Abstract excerpt
The Mov 34 mutation is a recessive embryonic lethal mutation caused by retroviral integration in the murine germline. This integration disrupts a transcription unit that appears to encode a novel protein. The Mov 34 proviral integration is located on mouse chromosome 8 and the human homolog of th...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Blotting, Southern
- Chromosome Mapping
- Chromosomes, Human, Pair 16
- Drosophila
- Genes, Recessive
- Humans
- Mice
- Molecular Sequence Data
- Mutagenesis, Insertional
- Proviruses
- Recombination, Genetic
- Sequence Homology, Nucleic Acid
- Transcription, Genetic