Article
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability.
Molecular and cellular biology - 1 Feb 2004
O'Donnell Niall, Zachara Natasha E, Hart Gerald W, Marth Jamey D
Abstract excerpt
The Ogt gene encodes a glycosyltransferase that links N-acetylglucosamine to serine and threonine residues (O-GlcNAc) on nuclear and cytosolic proteins. Efforts to study a mammalian model of Ogt deficiency have been hindered by the requirement for this X-linked gene in embryonic stem cell viabili...
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