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Article

Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel.

The Journal of general physiology - 1 Jun 1998

Filatov G N, Nguyen T P, Kraner S D, Barchi R L

Abstract excerpt

The D4/S4-5 interhelical region plays a role in sodium channel fast inactivation. Examination of S4-5 primary structure in all domains suggests a possible amphipathic helical conformation in which a conserved group of small hydrophobic residues occupies one contiguous surface with a more variable complement of nonpolar and polar residues on the opposite face. We evaluated this potential structure by replacing...

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Identifiers

PMID: 9607932
DOI: 10.1085/jgp.111.6.703
PMCID: PMC2217155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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