Article
Inactivation and secondary structure in the D4/S4-5 region of the SkM1 sodium channel.
The Journal of general physiology - 1 Jun 1998
Filatov G N, Nguyen T P, Kraner S D, Barchi R L
Abstract excerpt
The D4/S4-5 interhelical region plays a role in sodium channel fast inactivation. Examination of S4-5 primary structure in all domains suggests a possible amphipathic helical conformation in which a conserved group of small hydrophobic residues occupies one contiguous surface with a more variable...
Topics
- Animals
- Cells, Cultured
- Cysteine
- Electric Stimulation
- Electrophysiology
- Kinetics
- Membrane Potentials
- Models, Structural
- Mutagenesis, Site-Directed
- Mutation
- Patch-Clamp Techniques
- Rats
- Sodium Channel Blockers
- Sodium Channels
- Sulfhydryl Reagents