Article
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.
Cancer research - 1 Dec 1996
Goggins M, Schutte M, Lu J, Moskaluk C A, Weinstein C L, Petersen G M, Yeo C J, Jackson C E, Lynch H T, Hruban R H, Kern S E
Abstract excerpt
Germline mutations in BRCA2 predispose carriers to the development of breast, ovarian, and a variety of other cancers. The original localization of the BRCA2 gene was aided by its homozygous deletion in a pancreatic carcinoma; indeed, an excess of pancreatic carcinoma has been seen in some BRCA2 cancer families. To determine the involvement of BRCA2 in pancreatic carcinomas, we screened for BRCA2 alterations in...
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