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Article

Increased prevalence of the BRCA2 polymorphic stop codon K3326X among individuals with familial pancreatic cancer.

Oncogene - 19 May 2005

Martin Sean T, Matsubayashi Hiroyuki, Rogers Carmelle D, Philips Juliet, Couch Fergus J, Brune Kieran, Yeo Charles J, Kern Scott E, Hruban Ralph H, Goggins Michael

Abstract excerpt

Germline BRCA2 mutations predispose to the development of pancreatic cancer. A polymorphic stop codon in the coding region of BRCA2 (K3326X) has been described, and although an initial epidemiological study suggested it was not disease causing, subsequent studies have been inconclusive. To investigate the biological significance of the K3326X polymorphism, we determined its prevalence in patients with sporadic...

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Identifiers

PMID: 15806175
DOI: 10.1038/sj.onc.1208411

Genes

BRCA2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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