Article
Role of BRCA1 and BRCA2 mutations in pancreatic cancer.
Gut - 1 May 2007
Greer Julia B, Whitcomb David C
Abstract excerpt
Germline mutations in the tumour suppressor genes breast cancer antigen gene (BRCA)1 and BRCA2 have been proven to portend a drastically increased lifetime risk of breast and ovarian cancers in the individuals who carry them. A number of studies have shown that the third most common cancer associated with these mutations is pancreatic cancer. BRCA1/2 mutations are characterised by "allelic" or "phenotypic"...
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