Article
BRCA2 germline mutations in familial pancreatic carcinoma.
Journal of the National Cancer Institute - 5 Feb 2003
Hahn Stephan A, Greenhalf Bill, Ellis Ian, Sina-Frey Mercedes, Rieder Harald, Korte Birgit, Gerdes Berthold, Kress Ralf, Ziegler Andreas, Raeburn John A, Campra Donata, Grützmann Robert, Rehder Helga, Rothmund Matthias, Schmiegel Wolff, Neoptolemos John P, Bartsch Detlef K
Abstract excerpt
BACKGROUND: Although as many as 10% of pancreatic cancer cases may have an inherited component, familial pancreatic cancer has not been linked to defects in any specific gene. Some studies have shown that families with germline mutations in the breast cancer susceptibility gene BRCA2 have an increased risk of breast and ovarian cancers, as well as a modestly increased risk of pancreatic cancer. To study these...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.