Article
Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Oct 2017
Shindo Koji, Yu Jun, Suenaga Masaya, Fesharakizadeh Shahriar, Cho Christy, Macgregor-Das Anne, Siddiqui Abdulrehman, Witmer P Dane, Tamura Koji, Song Tae Jun, Navarro Almario Jose Alejandro, Brant Aaron, Borges Michael, Ford Madeline, Barkley Thomas, He Jin, Weiss Matthew J, Wolfgang Christopher L, Roberts Nicholas J, Hruban Ralph H, Klein Alison P, Goggins Michael
Abstract excerpt
Purpose Deleterious germline mutations contribute to pancreatic cancer susceptibility and are well documented in families in which multiple members have had pancreatic cancer. Methods To define the prevalence of these germline mutations in patients with apparently sporadic pancreatic cancer, we sequenced 32 genes, including known pancreatic cancer susceptibility genes, in DNA prepared from normal tissue obtained...
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