Article
The prevalence of BRCA2 mutations in familial pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2007
Couch Fergus J, Johnson Michele R, Rabe Kari G, Brune Kieran, de Andrade Mariza, Goggins Michael, Rothenmund Heidi, Gallinger Steven, Klein Alison, Petersen Gloria M, Hruban Ralph H
Abstract excerpt
Mutations in the BRCA2 gene have been implicated in pancreatic cancer susceptibility through studies of high-risk breast and ovarian cancer families. To determine the contribution of mutations in BRCA2 to familial pancreatic cancer, we screened affected probands from 151 high-risk families identified through pancreatic cancer clinics for germ-line BRCA2 mutations. Of these families, 118 had two or more first- and...
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