Article
Absence of germline BRCA1 mutations in familial pancreatic cancer patients.
Cancer biology & therapy - 1 Jan 2009
Axilbund Jennifer E, Argani Pedram, Kamiyama Mihoko, Palmisano Emily, Raben Marian, Borges Michael, Brune Kieran A, Goggins Michael, Hruban Ralph H, Klein Alison P
Abstract excerpt
Recent studies have suggested that germ line mutations in the BRCA1 gene may confer an increased risk of developing pancreatic cancer. To determine if BRCA1 mutations explain a significant proportion of familial pancreatic cancer, we sequenced the BRCA1 gene in a large series of well-characterized patients with familial pancreatic cancer and we evaluated the pathology of breast neoplasms that developed in...
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