Article
Mutations in the BRCA2 gene in hepatocellular carcinomas.
Cancer research - 15 Oct 1996
Katagiri T, Nakamura Y, Miki Y
Abstract excerpt
To investigate whether the BRCA2 gene plays a role in carcinogenesis of hepatocellular carcinomas or pancreatic cancers in view of frequent losses of heterozygosity on chromosome 13q12-13 in those tumors, we screened the entire coding region of this gene for mutations in 60 hepatocellular carcinomas and 36 pancreatic cancers. No alteration was found in any of the pancreatic cancers examined, but three mutations...
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