Article
Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats.
Carcinogenesis - 1 Nov 1996
Tamano S, Ward J M, Diwan B A, Keefer L K, Weghorst C M, Calvert R J, Henneman J R, Ramljak D, Rice J M
Abstract excerpt
Glyceryl trinitrate (GTN) was previously reported to induce hepatocellular carcinoma (HCC) in rats after prolonged feeding. The present experiments were undertaken to evaluate the histogenesis and molecular biology of these tumors and the possible role of nitric oxide (NO), a GTN metabolite, in their development. Male F344 rats received a single i.g. intubation of GTN (1.2 g/kg) at 6 weeks of age and/or a diet...
Topics
- Animals
- Base Sequence
- Genes, p53
- Genes, ras
- Glutathione Transferase
- Hepatectomy
- Immunohistochemistry
- Liver Neoplasms, Experimental
- Male
- Molecular Sequence Data
- Mutagens