Article
Liver tumorigenesis by Helicobacter hepaticus: considerations of mechanism.
In vivo (Athens, Greece) - 1 Jan 2000
Canella K A, Diwan B A, Gorelick P L, Donovan P J, Sipowicz M A, Kasprzak K S, Weghorst C M, Snyderwine E G, Davis C D, Keefer L K, Kyrtopoulos S A, Hecht S S, Wang M, Anderson L M, Rice J M
Abstract excerpt
A new animal model for the causation of liver tumors via a bacterial infection presented itself fortuitously in the form of a new species, Helicobacter hepaticus. This species of Helicobacter colonizes the hepatic bile canaliculi in susceptible strains of mice, resulting in hepatitis and hepatocellular and hepatocholangiolar adenomas and carcinomas. The mechanism by which this infection leads to cancer is...
Topics
- Alkylation
- Animals
- Carcinogens
- DNA Adducts
- DNA Damage
- Helicobacter Infections
- Liver Neoplasms
- Mice
- Mutation
- Oxidative Stress