Article
Review of studies concerning the tumorigenicity of 2-butoxyethanol in B6C3F1 mice and its relevance for human risk assessment.
Journal of toxicology and environmental health. Part B, Critical reviews - 1 Jan 2000
Boatman Rodney, Corley Richard, Green Trevor, Klaunig James, Udden Mark
Abstract excerpt
The U.S. National Toxicology Program (NTP) has completed 2-yr inhalation exposures in rats and mice with 2-butoxyethanol (BE). This review concerns the most significant findings from those studies and describes recent research into the mechanistic aspects of BE-mediated tumorigenesis in the mouse and the relevance of such effects to humans. Two tumor types were increased in B6C3F1 mice leading to the...
Topics
- Administration, Oral
- Animals
- Carcinogenicity Tests
- Carcinogens
- Cocarcinogenesis
- DNA Damage
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Ethylene Glycols
- Female
- Hemangiosarcoma
- Hemolysis
- Humans