Article
Ha-ras mutations in N-nitrosomorpholine-induced lesions and inhibition of hepatocarcinogenesis by antisense sequences in rat liver.
International journal of cancer - 4 Sept 1997
Baba M, Yamamoto R, Iishi H, Tatsuta M
Abstract excerpt
To evaluate the application of Ha-ras mRNA antisense oligonucleotide therapy for liver tumors, we examined the frequency and types of mutation in codon 61 of the Ha-ras oncogene in preneoplastic lesions and hepatocellular carcinomas induced by N-nitrosomorpholine (NNM) in rats. Thirty-seven perce...
Topics
- Animals
- Base Sequence
- Carcinoma, Hepatocellular
- Evaluation Studies as Topic
- Genes, ras
- Injections, Intraperitoneal
- Liver Neoplasms
- Male
- Mutation
- Nitrosamines
- Oligonucleotides, Antisense
- Point Mutation
- Precancerous Conditions
- Rats
- Rats, Sprague-Dawley