Article
Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice.
Carcinogenesis - 1 Nov 1996
Woloschak G E, Paunesku T, Libertin C R, Chang-Liu C M, Churchill M, Panozzo J, Grdina D, Gemmell M A, Giometti C
Abstract excerpt
Mice bearing the autosomal recessive mutation 'wasted' (wst/wst) express a disease syndrome characterized by neurologic dysfunction, immunodeficiency, and increased sensitivity to the killing effects of ionizing radiation relative to normal littermates (wst/-) and to parental control mice (BCF1, BALB/c, and C57BL/6). Many of these abnormalities, evident as early as 21 days of age, have been localized to thymic...
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