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Article

Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms.

Genes & development - 1 May 2008

Dong Jie, Jimi Eijiro, Zhong Haihong, Hayden Matthew S, Ghosh Sankar

Abstract excerpt

Cells from a "knock-in" mouse expressing a NF-kappaB p65 mutant bearing an alanine instead of serine at position 276 (S276A) display a significant reduction of NF-kappaB-dependent transcription, even though the mutant p65 forms appropriate complexes that translocate normally to the nucleus and bind to DNA. Surprisingly, however, instead of the expected embryonic lethality from hepatocyte apoptosis seen in the...

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PMID: 18408078
DOI: 10.1101/gad.1657408
PMCID: PMC2335313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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