[Induction of hyperdiploidy and chromosome breaks in LIM1215 cells expressing the exogenous mutant p53].

Article

[Induction of hyperdiploidy and chromosome breaks in LIM1215 cells expressing the exogenous mutant p53].

Genetika - 1 Aug 1996

Agapova L S, Turovets N A, Ivanov A V, Il'inskaia G V, Chumakov P M

Abstract excerpt

The effect of modifications of p53 expression on the incidence of numerical and structural chromosome aberrations was studied. Infection of LIM1215 cells containing two alleles of the wild-type p53 gene (P53wt) with the recombinant viruses that expressed mutant cDNAs coding for human p53 (His273,...

Topics

Cell Line
Chromosome Aberrations
Gene Expression
Genes, p53
Humans
Karyotyping
Mutation
Polyploidy
Transfection
Tumor Suppressor Protein p53

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