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[Induction of hyperdiploidy and chromosome breaks in LIM1215 cells expressing the exogenous mutant p53].

Genetika - 1 Aug 1996

Agapova L S, Turovets N A, Ivanov A V, Il'inskaia G V, Chumakov P M

Abstract excerpt

The effect of modifications of p53 expression on the incidence of numerical and structural chromosome aberrations was studied. Infection of LIM1215 cells containing two alleles of the wild-type p53 gene (P53wt) with the recombinant viruses that expressed mutant cDNAs coding for human p53 (His273, Trp248, and His175) resulted in appearance of hyperdiploid cells in populations and an increased proportion of...

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PMID: 8964480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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