Article
[Stimulation of differentiation of LIM 1215 large intestinal tumor cells during expression of the p53 exogenous antioncogene or the activated ras oncogene].
Arkhiv patologii - 1 Jan 2000
Raĭkhlin N T, Volodina Iu L, Smirnova E A, Perevoshchikov A G, Chumakov P M, Kopnin B P
Abstract excerpt
The ability of exogenous p53 tumor-suppressor and activated N-PAS oncogene to influence differentiation state of human colon carcinoma LIM 1215 cells and their derivatives with acquired resistance to actinomycin D or methotrexate was analysed Introduction of retroviral construct expressing human wild-type (wt) p53 into LIM 1215 cells induced electron microscopic manifestations of enterocytic differentiation, i.e....
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