Article
[Influence of prothymosin alpha and its mutants on activity of the p53 tumor suppressor].
Molekuliarnaia biologiia - 1 Jan 2000
Zakharova N I, Sokolov V V, Rud'ko V V, Mel'nikov S V, Vartapetian A B, Evstaf'eva A G
Abstract excerpt
Overexpression of the nuclear oncoprotein prothymosin a enhanced and, in a reciprocal experiment, down-regulation of endogenous prothymosin alpha by RNA interference approach inhibited transcriptional activity of the p53 tumor suppressor in the reporter gene assay. Ectopic expression of prothymosin alpha enhanced not only p53-dependent transcription, but also intracellular level of p53 in HeLa (but not HCT116)...
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