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Article

[Synthesis and functional studies on nucleic acids. Problems related to synthetic ras genes].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Oct 1994

Ohtsuka E

Abstract excerpt

Synthesis of a gene for an oncoprotein, ras p21 and its functions are described. Point mutations in hot spots of ras genes have been found in human cancer cells and produce activated p21 which result in transformation of cultured NIH3T3 cells. To produce normal and activated p21 in quantity for biochemical and structural studies, genes encoding these proteins were synthesized and expressed in E. coli. Normal and...

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Identifiers

PMID: 7807379
DOI: 10.1248/yakushi1947.114.10_747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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