Article
Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells.
Endocrinology - 1 Jan 1994
Olson M F, Schimmer B P
Abstract excerpt
Mutant isolates from the Y1 mouse adrenocortical tumor cell line (designated Y1DR) were previously shown to resist homologous desensitization of adenylyl cyclase via endogenous ACTH receptors or transfected beta 2-adrenergic receptors. To further localize the site of the DR mutation, we examined...
Topics
- Adrenal Glands
- Adrenergic beta-Agonists
- Animals
- Binding Sites
- GTP-Binding Proteins
- Guanylyl Imidodiphosphate
- Homeostasis
- Iodocyanopindolol
- Isoproterenol
- Mice
- Mutation
- Pindolol
- Receptors, Adrenergic, beta
- Tumor Cells, Cultured