Article
The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1996
Gage P J, Brinkmeier M L, Scarlett L M, Knapp L T, Camper S A, Mahon K A
Abstract excerpt
Two nonallelic dwarfing mutations in mice define genes important for pituitary development and function. Mice homozygous for either the Ames (df) or Snell (Pit 1dw) dwarf mutations exhibit severe proportional dwarfism, hypothyroidism, and infertility due to the cytodifferentiation failure of three anterior pituitary cell types: thyrotropes, somatotropes, and lactotropes. Analysis of double heterozygotes and...
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