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Transcriptome analyses of female somatotropes and lactotropes reveal novel regulators of cell identity in the pituitary

21 Sept 2018

Abstract excerpt

The differentiation of the hormone-producing cell lineages of the anterior pituitary represents an informative model of mammalian cell fate determination. The generation and maintenance of two of these lineages, the GH-producing somatotropes and prolactin (PRL)-producing lactotropes, are dependent on the pituitary-specific transcription factor POU1F1. Whereas POU1F1 is expressed in both cell types, and plays a...

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PMID: 30247555
DOI: 10.1210/en.2018-00587

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