Article
Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope.
Development (Cambridge, England) - 1 Mar 1994
Lin S C, Li S, Drolet D W, Rosenfeld M G
Abstract excerpt
The anterior pituitary provides a model to study the molecular mechanisms responsible for emergence of distinct cell types within an organ. Dwarf mice (Snell) that express a mutant form of the tissue-specific POU-domain transcription factor Pit-1 fail to generate three cell types, including the t...
Topics
- Animals
- Base Sequence
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression
- Genotype
- In Situ Hybridization, Fluorescence
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Morphogenesis
- Pituitary Gland, Anterior
- Thyrotropin
- Transcription Factor Pit-1
- Transcription Factors