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<i>Lhx4</i>and<i>Prop1</i>are required for cell survival and expansion of the pituitary primordia

15 Sept 2002

Abstract excerpt

Deficiencies in the homeobox transcription factors LHX4 and PROP1 cause pituitary hormone deficiency in both humans and mice. Lhx4 and Prop1 mutants exhibit severe anterior pituitary hypoplasia resulting from limited differentiation and expansion of most specialized cell types. Little is known about the mechanism through which these genes promote pituitary development. In this study we determined that the...

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PMID: 12183375
DOI: 10.1242/dev.129.18.4229

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