Article
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.
Nature - 28 Nov 1996
Sornson M W, Wu W, Dasen J S, Flynn S E, Norman D J, O'Connell S M, Gukovsky I, Carrière C, Ryan A K, Miller A P, Zuo L, Gleiberman A S, Andersen B, Beamer W G, Rosenfeld M G
Abstract excerpt
The gene apparently responsible for a heritable form of murine pituitary-dependent dwarfism (Ames dwarf, df) has been positionally cloned, identifying a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of Pit-1 (Prop-1). The df phenotype results from an apparen...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Cell Lineage
- DNA-Binding Proteins
- Dwarfism, Pituitary
- Female
- Gene Expression
- Homeodomain Proteins
- Hypothalamus
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data