Article
Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility.
Human molecular genetics - 15 May 2001
Cushman L J, Watkins-Chow D E, Brinkmeier M L, Raetzman L T, Radak A L, Lloyd R V, Camper S A
Abstract excerpt
The 'paired'-like homeodomain transcription factor Prop1 is essential for the expansion of the pituitary primordia and for the differentiation and/or function of the hormone-producing cells of the anterior pituitary gland. Prop1 expression is normally extinguished before transcription of most differentiation markers is initiated. We report that constitutive expression of Prop1 interferes with anterior pituitary...
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