Article
Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin.
Infection and immunity - 1 Dec 1996
Magagnoli C, Manetti R, Fontana M R, Giannelli V, Giuliani M M, Rappuoli R, Pizza M
Abstract excerpt
Heat-labile toxin (LT) is a protein related to cholera toxin, produced by enterotoxigenic Escherichia coli strains, that is organized as an AB5 complex. A number of nontoxic derivatives of LT, useful for new or improved vaccines against diarrheal diseases or as mucosal adjuvants, have been constr...
Topics
- Endopeptidases
- Enterotoxins
- Escherichia coli
- Hot Temperature
- Mutation
- Substrate Specificity