Article
Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin.
Infection and immunity - 1 Dec 1996
de Haan L, Verweij W R, Feil I K, Lijnema T H, Hol W G, Agsteribbe E, Wilschut J
Abstract excerpt
The Escherichia coli heat-labile enterotoxin (LT) is a potent inducer of mucosal immune responses. In a previous study (L. DeHaan, W. R. Verweij, M. Holtrop, E. Agsteribbe, and J. Wilschut, Vaccine 14:620-626, 1996), we have shown that efficient induction of an LTB-specific mucosal immune respons...
Topics
- Adenosine Diphosphate
- Animals
- Enterotoxins
- Escherichia coli
- Hot Temperature
- Immunity, Mucosal
- Mice
- Mutation