Article
Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.
Vaccine - 21 Mar 2001
Pizza M, Giuliani M M, Fontana M R, Monaci E, Douce G, Dougan G, Mills K H, Rappuoli R, Del Giudice G
Abstract excerpt
Most vaccines are still delivered by injection. Mucosal vaccination would increase compliance and decrease the risk of spread of infectious diseases due to contaminated syringes. However, most vaccines are unable to induce immune responses when administered mucosally, and require the use of strong adjuvant on effective delivery systems. Cholera toxin (CT) and Escherichia coli enterotoxin (LT) are powerful mucosal...
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