Article
Mutants of Escherichia coli heat-labile enterotoxin as an adjuvant for nasal influenza vaccine.
Vaccine - 1 Jan 2000
Komase K, Tamura S, Matsuo K, Watanabe K, Hattori N, Odaka A, Suzuki Y, Kurata T, Aizawa C
Abstract excerpt
The effectiveness and safety of known mutants of Escherichia coli heat-labile enterotoxin (LT) as an adjuvant for nasal influenza vaccine were examined. Six mutants, called LT7K (Arg to Lys), LT61F (Ser to Phe), LT112K (Glu to Lys), LT118E (Gly to Glu), LT146E (Arg to Glu) and LT192G (Arg to Gly) were constructed by the replacement of one amino acid at one position of the A1 subunit to another using site-directed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.