Mutants of Escherichia coli heat-labile enterotoxin as an adjuvant for nasal influenza vaccine.

doi:10.1016/s0264-410x(97)00176-x

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Article

Mutants of Escherichia coli heat-labile enterotoxin as an adjuvant for nasal influenza vaccine.

Vaccine - 1 Jan 2000

Komase K, Tamura S, Matsuo K, Watanabe K, Hattori N, Odaka A, Suzuki Y, Kurata T, Aizawa C

Abstract excerpt

The effectiveness and safety of known mutants of Escherichia coli heat-labile enterotoxin (LT) as an adjuvant for nasal influenza vaccine were examined. Six mutants, called LT7K (Arg to Lys), LT61F (Ser to Phe), LT112K (Glu to Lys), LT118E (Gly to Glu), LT146E (Arg to Glu) and LT192G (Arg to Gly)...

Topics

Adjuvants, Immunologic
Administration, Intranasal
Animals
Bacterial Toxins
Enterotoxins
Escherichia coli
Escherichia coli Proteins
Female
Influenza Vaccines
Mice
Mice, Inbred BALB C
Mutation

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