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Article

APC mutations are infrequent but present in human lung cancer.

Cancer letters - 30 Apr 2004

Ohgaki Hiroko, Kros Johan M, Okamoto Yoshikazu, Gaspert Ariana, Huang Hervé, Kurrer Michael O

Abstract excerpt

Recent studies have revealed the presence of beta-catenin mutations in a small subset of human and rat lung carcinomas, suggesting the involvement of the Wnt pathway in pulmonary carcinogenesis. LOH on chromosome 5q (APC locus) is frequent in lung cancer, but previous studies have found no adenomatous polyposis coli (APC) mutations. In this study, we screened 114 human lung cancer specimens for alterations in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15072829
DOI: 10.1016/j.canlet.2003.10.020

Genes

APC
GAA
AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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