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Article

Expression of the HsOrc1 Gene, a Human ORC1 Homolog, Is Regulated by Cell Proliferation via the E2F Transcription Factor

1 Dec 1996

Abstract excerpt

The initiation of DNA replication in Saccharomyces cerevisiae requires the action of a multisubunit complex of six proteins known as the origin recognition complex (ORC). The identification of higher eukaryotic homologs of several ORC components suggests a universal role for this complex in DNA replication. We now demonstrate that the expression of one of these homologs is regulated by cell proliferation....

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PMID: 8943353
DOI: 10.1128/mcb.16.12.6977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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