Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus

2 Sept 2003

Abstract excerpt

The sequential binding of the origin recognition complex (ORC), Cdc6p and the minichromosome maintenance proteins (MCM2-7) mediates replication competence at eukaryotic origins of DNA replication. The latent origin of Epstein-Barr virus, oriP, is a viral origin known to recruit ORC. OriP also binds EBNA1, a virally encoded protein that lacks any activity predicted to be required for replication initiation. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Polyomavirus and related diseases
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12953058
DOI: 10.1242/jcs.00708

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virusPMID 12953058Read ↗

Epstein-Barr Nuclear Antigen 1 (EBNA1)-dependent Recruitment of Origin Recognition Complex (Orc) on oriP of Epstein-Barr Virus with Purified ProteinsSemantic proximity Read ↗

Human DNA replication initiation factors, ORC and MCM, associate with <i>oriP</i> of Epstein–Barr virusSemantic proximity Read ↗

The Epstein-Barr Virus Episome Maneuvers between Nuclear Chromatin Compartments during ReactivationSemantic proximity Read ↗

The Linking Regions of EBNA1 Are Essential for Its Support of Replication and TranscriptionSemantic proximity Read ↗

The Epstein-Barr virus episome maneuvers between nuclear chromatin compartments during reactivationSemantic proximity Read ↗

Cellular transcription factors recruit viral replication proteins to activate the Epstein–Barr virus origin of lytic DNA replication, oriLytSemantic proximity Read ↗

HCF1 and OCT2 Cooperate with EBNA1 To Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr VirusSemantic proximity Read ↗

EBNA1-Mediated Recruitment of a Histone H2B Deubiquitylating Complex to the Epstein-Barr Virus Latent Origin of DNA ReplicationSemantic proximity Read ↗

A WD-repeat protein stabilizes ORC binding to chromatin.Semantic proximity Read ↗

The Amino Terminus of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Contains AT Hooks That Facilitate the Replication and Partitioning of Latent EBV Genomes by Tethering Them to Cellular ChromosomesSemantic proximity Read ↗

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cellsSemantic proximity Read ↗

Eucaryotic replication origin binding proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.