Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygous disruption of the DNA topoisomerase I gene confers cellular resistance to camptothecin in human cells.

Biological & pharmaceutical bulletin - 1 Apr 2009

Toyoda Eriko, Kurosawa Aya, Fujii Michihiko, Adachi Noritaka

Abstract excerpt

DNA topoisomerase I (Top1) is a ubiquitous nuclear enzyme that plays essential roles in various cellular processes, such as transcription or replication. Agents that target Top1, involving camptothecin and its derivatives, are among the most effective anticancer drugs used in the clinic. Previous work has suggested that the level of Top1 expression correlates with the cytotoxicity of camptothecin, but no direct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents, Phytogenic
Share to Blotting, Southern

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Western

Share to Camptothecin

Share to Cell Line, Tumor

Share to DNA Topoisomerases, Type I

Share to Drug Resistance, Neoplasm

Share to Gene Targeting

Source

Identifiers

PMID: 19336913
DOI: 10.1248/bpb.32.724

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygous disruption of the DNA topoisomerase I gene confers cellular resistance to camptothecin in human cells.PMID 19336913Read ↗

Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic AnalysesSemantic proximity Read ↗

TDP1 splice-site mutation causes HAP1 cell hypersensitivity to topoisomerase I inhibition.Semantic proximity Read ↗

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.Semantic proximity Read ↗

Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.Semantic proximity Read ↗

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.Semantic proximity Read ↗

Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin.Semantic proximity Read ↗

The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cellsSemantic proximity Read ↗

Detection of functional protein domains by unbiased genome-wide forward genetic screening.Semantic proximity Read ↗

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death.Semantic proximity Read ↗

The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1α Activity by Changing miR Expression Patterns in Human Cancer CellsSemantic proximity Read ↗

The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damageSemantic proximity Read ↗

Characterization of a novel topoisomerase I mutation from a camptothecin-resistant human prostate cancer cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.