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Article

Production of knockout mice by gene targeting in multipotent germline stem cells.

Developmental biology - 1 Dec 2007

Takehashi Masanori, Kanatsu-Shinohara Mito, Miki Hiromi, Lee Jiyoung, Kazuki Yasuhiro, Inoue Kimiko, Ogonuki Narumi, Toyokuni Shinya, Oshimura Mitsuo, Ogura Atsuo, Shinohara Takashi

Abstract excerpt

Spermatogonial stem cells can convert into embryonic stem (ES) cell-like multipotent germline stem (mGS) cells in vitro and produce germline chimeras by blastocyst microinjection. Although homologous recombination was previously demonstrated in mGS cells, spermatogenesis was not found in chimeras, suggesting that they are not competent for germline modification. Here we conducted detailed analysis of chimeric...

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PMID: 17959167
DOI: 10.1016/j.ydbio.2007.09.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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