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Article

Seizure suppression by top1 mutations in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Mar 2007

Song Juan, Hu Joyce, Tanouye Mark

Abstract excerpt

DNA topoisomerase I is an essential nuclear enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin condensation. Here we report the discovery of a seizure-suppressor mutant, top1(JS), which suppresses seizures in a Drosophila model of human epilepsy. A P-element mutagenesis screen using easily shocked seizure-sensitive mutant as a genetic background...

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Identifiers

PMID: 17360915
DOI: 10.1523/JNEUROSCI.3944-06.2007
PMCID: PMC6672588

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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