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Article

Analysis of expression and function of topoisomerase I and II during meiosis in male mice

1 Apr 1997

Abstract excerpt

Topoisomerases are nuclear enzymes that remove torsional stress in DNA. Their function is important for replication, transcription, chromosome condensation, and chromosome segregation during mitosis and meiosis. The goal of this work is to analyze both expression and function of topoisomerases during the meiotic stages of mammalian spermatogenesis. The patterns of expression of topoisomerase I and topoisomerase...

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PMID: 9094096
DOI: 10.1002/(sici)1098-2795(199704)46:4<489::aid-mrd7>3.0.co;2-k

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