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Article

Frequent clones of p53-mutated keratinocytes in normal human skin.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 1996

Jonason A S, Kunala S, Price G J, Restifo R J, Spinelli H M, Persing J A, Leffell D J, Tarone R E, Brash D E

Abstract excerpt

The multiple genetic hit model of cancer predicts that normal individuals should have stable populations of cancer-prone, but noncancerous, mutant cells awaiting further genetic hits. We report that whole-mount preparations of human skin contain clonal patches of p53-mutated keratinocytes, arisin...

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Identifiers

PMID: 8943054
DOI: 10.1073/pnas.93.24.14025
PMCID: PMC19488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8943054-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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