Article
The density of epidermal p53 clones is higher adjacent to squamous cell carcinoma in comparison with basal cell carcinoma.
The British journal of dermatology - 1 Feb 2004
Bäckvall H, Wolf O, Hermelin H, Weitzberg E, Pontén F
Abstract excerpt
BACKGROUND: It is well accepted that ultraviolet radiation from the sun can induce and promote growth of skin tumours. Skin cancer develops as a consequence of multiple genetic hits, where an initial, important step includes proliferation of cells susceptible to malignant transformation. Foci of morphologically normal epidermal keratinocytes overexpressing p53 protein are common in chronically sun-exposed skin....
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