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Article

Low frequency of genetic change in p53 immunopositive clones in human epidermis.

The Journal of investigative dermatology - 1 Dec 1999

Tabata H, Nagano T, Ray A J, Flanagan N, Birch-MacHin M A, Rees J L

Abstract excerpt

Sun-exposed skin of Caucasians harbors thousands of p53-mutated clones, which are clinically invisible. Using whole mount immunostaining for p53 or Ki67 antigens, p53 sequencing, and loss of heterozygosity analysis, we have further characterised these clones. Loss of heterozygosity for the alleles examined is uncommon with the exception of 9q, which occurred in 28.3% of the samples. P53 clones are more common and...

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Share to Skin Neoplasms
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Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10594739
DOI: 10.1038/sj.jid.5600549.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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