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Article

Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice.

Human molecular genetics - 15 Nov 2004

Nasonkin Igor O, Ward Robert D, Raetzman Lori T, Seasholtz Audrey F, Saunders Thomas L, Gillespie Patrick J, Camper Sally A

Abstract excerpt

Mutations in Prophet of PIT1 (Prop1), one of several homeodomain transcription factors that are required for the development of the anterior pituitary gland, are the predominant cause of MPHD (multiple pituitary hormone deficiency) in humans. We show that deletion of Prop1 in mice causes severe pituitary hypoplasia with failure of the entire Pit1 lineage and delayed gonadotrope development. The pituitary hormone...

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Source

Identifiers

PMID: 15459176
DOI: 10.1093/hmg/ddh311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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