Article
Pituitary hormone deficiencies due to transcription factor gene alterations.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Dec 2004
Reynaud R, Saveanu A, Barlier A, Enjalbert A, Brue T
Abstract excerpt
Mechanisms that control pituitary development are gradually better understood. They involve molecular signals from surrounding structures and the expression of a cascade of homeodomain transcription factors. Mutations of these transcription factors cause defects of embryologic development of the anterior pituitary responsible for isolated or multiple pituitary hormone deficiencies (respectively, IPHD and MPHD) in...
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